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Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al

However, chronic stimulation of these paracrine myofibroblast pathways in IBD raises theoretical safety concerns regarding stricturing, fibrosis risk, and the necessity for rigorous dysplasia surveillance, which remain critical hurdles for long-term clinical development

The team initially expected lower GLP-1 levels in those with the variant

doi: 10.1038/s41577-022-00713-4 6 Martin-ViasJJQuigleyEM
